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Camptothecine

Camptothecine

CAS : 7689-03-4
Molecular Formula : C20H16N2O4
Formula Weight : 348.35g/mol
Description :
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native in China. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction.

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