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Floxuridine Pharmacodynamics

Floxuridine Pharmacodynamics

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of corpuscle division. This selectively kills rapidly adding cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents accustomed pyrimidines from getting congenital into DNA during the S appearance of the corpuscle cycle. Flurouracil (the end-product of catabolism of floxuridine) blocks an agitator which converts cytosine nucleosides into the deoxy derivative. In addition, DNA amalgam is added inhibited because fluoruracil blocks the assimilation of the thymdine nucleotide into the DNA strand.