Rimantadine Mechanism of Resistance
Resistance occurs due to point mutations in the M gene of bacilli which leads to individual amino acerbic substitutions in the transmembrane area of the M2 protein. This allows the virus to uncoat in the attendance of rimantadine. Resistant variants appearance cross-resistance to amantadine, rimantadine, and accompanying compounds. Consequently, college biologic doses or another drugs with the aforementioned antiviral ambition are clumsy to affected this problem.