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Terfenadine

Terfenadine

CAS : 50679-08-8
Molecular Formula : C32H41NO2
Formula Weight : 471.67
Description : 
Terfenadine is an antihistamine formerly used for the treatment of allergic conditions.Terfenadine is a prodrug, generally completely metabolised to the active form fexofenadine by the intestinal cytochrome P450 CYP3A4 isoform. Due to this presystemic gut wall metabolism terfenadine normally is not measurable in the plasma. Terfenadine itself, however, has a cardiotoxic effect in higher doses while its metabolites have no such effect. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods like grapefruit.

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